Broccoli is known to have a positive impact on human health, with studies showing that increased consumption of this vegetable can reduce the risk of cancer and type 2 diabetes. Now, researchers at Pennsylvania State University have discovered that specific molecules in broccoli can dock onto receptors in mice, protecting the lining of the small intestine and preventing the development of diseases. The study found that certain molecules in broccoli, called Aryl-Hydrocarbon-Receptor-Ligands, bind to a protein known as the Aryl-Hydrocarbon-Receptor, which triggers a series of activities that influence the functions of small intestine cells. The research suggests that broccoli and other cruciferous vegetables should be part of a balanced and healthy diet.
The small intestine plays an essential role in allowing beneficial water and nutrients into the body while keeping out potentially harmful particles and bacteria. The lining of the small intestine is made up of various cells, including enterocytes, which absorb water and nutrients, and goblet cells, which produce a protective mucus layer on the intestinal wall. The researchers found that certain molecules in broccoli can bind to the Aryl-Hydrocarbon-Receptor, a protein that acts as a transcription factor, and trigger a range of activities that affect the functions of small intestine cells. In a study involving mice, the researchers fed one group a diet containing 15% broccoli, which is equivalent to approximately 3.5 cups per day for humans. The control group was fed a standard laboratory diet without broccoli. The researchers found that the mice that did not receive broccoli had impaired small intestine function, which is associated with various diseases.
The study’s lead author, Gary H. Perdew, explained that the research helps to decode the processes that occur in the body when we eat broccoli and other foods. He added that the study provides compelling evidence that cruciferous vegetables, such as broccoli, cabbage, and Brussels sprouts, should be part of a healthy and balanced diet. The research suggests that broccoli and other cruciferous vegetables can serve as natural sources of AHR-Ligands and that a diet rich in these ligands can contribute to the resilience of the small intestine. The study highlights the importance of a healthy diet in maintaining good health and preventing diseases.
