A new study published in the journal Science Advances has found that bacteria responsible for causing gum disease, known as Porphyromonas gingivalis, can also contribute to the development of Alzheimer’s disease. The bacteria can enter the brain and release toxic enzymes that damage neurons, leading to the development of Alzheimer’s. The study focused on the link between gum disease and Alzheimer’s, as individuals with severe gum disease are more likely to develop the disease. The researchers found that the toxic enzyme Gingipaine was present in the brains of Alzheimer’s patients, and that the enzyme was responsible for causing inflammation and the formation of beta-amyloid protein, which is typically found in the brains of Alzheimer’s patients.
The study also found that a molecule that can cross the blood-brain barrier was able to block the effects of Gingipaine in the brain, reducing the amount of protein buildup and neuron damage. The researchers suggest that this molecule could be used to slow or even stop the progression of Alzheimer’s in patients. Clinical trials with human subjects have already begun to test the effectiveness of this molecule.
The researchers also recommend regular dental hygiene practices, such as brushing and flossing, to prevent the buildup of gum disease bacteria and reduce the risk of developing Alzheimer’s. However, they caution that Alzheimer’s is not solely caused by gum disease bacteria and that further research is needed to fully understand the disease.
